The Value Of Peptones For Enhancing Biopharmaceutical Productivity
By Ashwin Gurunathan and Stacy Holdread, Thermo Fisher Scientific

Peptones, versatile protein hydrolysates derived from various sources, have become essential media additives in biopharmaceutical production. Their nutritional diversity and improved lot-to-lot consistency make them valuable tools for optimizing bioprocesses. While peptones offer significant benefits, concerns about their variability and impact on process consistency persist. However, for many biopharmaceutical applications, including monoclonal antibodies, vaccines, and cultured meat, peptones have demonstrated substantial improvements in titer and other key product attributes.
Recent advancements in cell culture, media feeds, supplements, cell lines, and production processes have served to transform biomanufacturing’s consistency and productivity in the last decade. This is equally true for peptones, which have undergone significant optimization that has resulted in much more consistent and high-quality supplements than those produced in the past or manufactured for other industries. Tighter and more relevant specs around bioburden and endotoxins, combined with improved analytical capabilities supporting their characterization and enhanced monitoring for key components, have made peptones a well-standardized material for use in bioprocessing.
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