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WHITE PAPERS AND CASE STUDIES

• Roche Cuts Feasibility Process by 36%

  Discover the solutions to how an industry pioneer and veteran biotech struggled with complexity and consistency when it came to its approach to clinical trial feasibility.

• Measuring Blast Wave Energy

  Students and researchers at The Colorado School of Mines used shadowgraphy to measure the blast waves created by a standard electric detonators. The team compared a fluid-desensitized oil and gas detonator to a standard mining and construction detonator.

• Reduce Product Loss In Biopharma To Save Costs

  A a global biotechnology company producing high-value mAbs in batch sizes from 10l to 700l faced the challenge of high loss rates with single use bags at sub-zero temperatures. Here's how they solved it.

• Patient Diversity Case Study: RWD Solutions

  A clinical trial sponsor, lagging in recruitment of Hispanic and Asian patients, was looking to diversify participants for its NASH study. See how by leveraging medical claims and diversity data, the sponsor identified relevant patients meeting the trial’s I/E criteria, broken out by race and gender.

• Quality By Design: The Highest-Standard Approach To Process Validation

  The challenge was to develop and validate manufacturing processes for two novel molecules, one in phase 1 development and the other in phase 3.

• MBBR Technology Helps Plant Maintain Discharge Compliance, Achieve Sustainable Growth

  A bacon processing plant in the Midwest was overloaded by more than 50%. Even though the system continued to maintain compliance, the plant proactively decided to expand its wastewater treatment facility to ensure they met their growing demand and maintained their standing as exemplary corporate citizens and environmental stewards.

• JLA Group Reduces Travel, Increases Productivity, And Improves SLA Performance With New Scheduling & Route Planning Solution

  The JLA Group is a UK leader for the distribution, rental and servicing of commercial equipment and regulatory compliance solutions across Laundry, Catering, Heating & A/C, and Fire Safety. JLA is very pleased with their choice of FAST LEAN SMART to optimise appointments and route planning for their 400 field engineers.

• The PI System And The Los Angeles Department Of Water And Power: A Winning Combination

  The Los Angeles Department of Water and Power (LADWP) is constantly preparing for an array of challenges ranging from droughts, wildfires, and earthquakes to aging pipes to optimizing operations such as pumps, water loss, and water quality treatment. Water utilities like LADWP are also looking for ways to improve customer service while safeguarding water storage and delivery systems.

• First Clinical Trial Using Stem Cell Therapy To Treat Septic Shock

   An Ottawa Hospital Research Institute’s Cell Manufacturing Facility successfully conducted a Phase I clinical trial examining the safety and efficacy of allogeneic bone marrow-derived MSCs as a treatment for patients experiencing septic shock. Before initiating clinical Phase II studies, the protocol for generating large quantities of MSCs had to be established to reduce end-product variability, minimize production costs, and to ensure sufficient yield to treat multiple patients. Maximizing the yield of viable cells proved challenging in a limited footprint.

• Successful Mixing Of Medical Paste

  A manufacturer was producing medical paste using a 5 - 10 gallon drum using a simple propeller mixer. They were unable to produce the product quantities needed quickly and the small batches they were able to make were taking a long time. The FMX25 helped them to produce larger batches in a much shorter time and improve the quality of the product which was consistent from batch-to-batch.

• Validating Your Ballast Water Management System

  Bio-UV, a manufacturer of ballast water management systems (BWMS) that utilize UV disinfection, was looking for a reliable and accurate indicative analysis to validate the installation of their BWMS system during commissioning. Read the full case study to learn more.

• Flood Event Prompts Portable Back-Up Pump Solution For Potable Water Network

  When a storm event shut down both Southern Iowa Rural Water Association pump stations, it caused authorities to scramble to move water to their customers.